Weekend in Panama City: Best Things to Do in 48 Hours

Looking for the perfect weekend getaway? A trip to Panama City, Panama gives you history, culture, nightlife, and adventure all in one. Known for the iconic Panama Canal, the vibrant streets of Casco Viejo, and a buzzing dining scene, Panama City is an underrated gem in Central America. With just 48 hours, you can experience the best things to do in Panama City and leave feeling like you’ve had a true mix of city excitement and tropical escape.

Day 1: Casco Viejo, the Panama Canal & Rooftop Nightlife

Morning: Explore Casco Viejo

Start your weekend in Panama City with a stroll through Casco Viejo (Old Quarter), a UNESCO World Heritage Site. This historic neighborhood is full of cobblestone streets, colorful colonial buildings, boutique shops, and lively plazas. Top things to see include Plaza de la Independencia, the Metropolitan Cathedral, and the National Theatre. Don’t forget to stop for coffee at a trendy café like Café Unido or Sisu Coffee Studio.

Afternoon: Visit the Panama Canal & Seafood Market

No Panama City itinerary is complete without seeing the Panama Canal. Head to the Miraflores Locks Visitor Center to watch giant cargo ships pass through and learn about one of the world’s greatest engineering marvels. Afterward, visit the Mercado de Mariscos (Seafood Market) for fresh, inexpensive ceviche and local seafood with waterfront views.

Evening: Rooftop Bars in Casco Viejo

Casco Viejo comes alive at night, making it one of the best things to do in Panama City after dark. For panoramic views, head to rooftops like Tantalo, CasaCasco, or Selina Rooftop. For dinner, try Sabroso which allows visitors to get a glimpse of Panamanian culture and enjoy local cuisine.

Pro Tip: all sights can be seen in a few hours with Tomi Tours in cute Volkswagens.

Day 2: Amador Causeway, Parks & Panama City Nightlife

Morning: Bike Along the Amador Causeway

Kick off day two at the Amador Causeway, a scenic roadway connecting four small islands. Rent a bike or scooter and enjoy breathtaking views of the Panama Canal and city skyline. Make a stop at the Biomuseo, designed by Frank Gehry, for a fun and colorful introduction to Panama’s biodiversity.

Afternoon: Hike Metropolitan Natural Park

For nature lovers, Metropolitan Natural Park is a must. Just minutes from downtown, this tropical rainforest offers trails where you can spot sloths, toucans, and monkeys. The summit rewards you with sweeping views of the city.

Evening: Panama City Nightlife

End your weekend in Panama City with a night out. If you’re looking for dancing, check out Casa Jaguar or Marietta for reggaetón and Latin beats. For something more relaxed, La Rana Dorada offers local craft beers in a lively pub setting. Foodies can enjoy dinner at Santa Rita for elevated local dishes or grab casual pizza at Barrio Pizza in Casco Viejo. You can also enjoy bar hopping with The OG Bar Crawl where they will take you to the hottest bars in Panama City.

Why Panama City Is the Perfect Weekend Trip

In just two days, you can experience a mix of history, culture, nightlife, and nature—making Panama City one of the best weekend destinations in Central America. Whether you’re exploring the historic charm of Casco Viejo, marveling at the Panama Canal, or enjoying rooftop cocktails with a skyline view, there’s something for every traveler.

✨ Pro Tip: If you have an extra day, take a short trip to San Blas Islands or Taboga Island for white sand beaches and turquoise waters. (Which I highly recommend)

Final Thoughts

Spending a weekend in Panama City means embracing contrasts: modern skyscrapers beside historic ruins, rainforest trails minutes from downtown, and traditional Panamanian flavors served in world-class restaurants. If you’re looking for a destination that’s exciting, affordable, and unforgettable, Panama City, Panama should be at the top of your travel list.